ABSTRACT
Background: Chronic constipation is one of the most common gastrointestinal disorders. It has negative effects on the patients' quality of life, and their productivity, and results in a high economic burden on the healthcare services. The aim of the present study was to estimate the prevalence of chronic constipation and its associated factors in pars cohort study [PCS]
Methods: A cross-sectional study was conducted on the baseline data of the PCS. Data gathering was done by structured questionnaire and physical examination. A total of 9264 subjects aged between 40 and 75 years were enrolled in the PCS. Diagnosis of chronic constipation was done using Rome IV criteria. Multivariable binary logistic regression was applied for data analysis
Results: A total of 752 [8.1%] participants were diagnosed as having chronic constipation [9.3% of female and 6.7% of male participants]. Older age [OR: 1.55, 95% CI:1.31-1.83], physical activity [OR: 0.56, 95% CI: 0.46-0.68], opium consumption [OR: 2.06, 95% CI: 1.63-2.60] , anxiety [OR: 1.38, 95% CI: 1.15-1.65], depression [OR: 1.22, 95% CI: 1.01-1.48], back pain or arthralgia [OR: 1.38, 95% CI: 1.14-1.67], insomnia [OR: 1.62, 95% CI: 1.36-1.93] and gastroesophageal reflux disease [OR: 1.51, 95% CI :1.28-1.78] were associated with the prevalence of constipation in the multivariable analysis
Conclusion: Chronic constipation was a common problem in the PCS population. Decreasing modifiable risk factors associated with constipation such as opium consumption and physical inactivity can reduce its prevalence and decrease burden of the disease.
ABSTRACT
Background: Prevalence of gastroesophageal reflux disease [GERD] is increasing worldwide. We aimed to estimate the prevalence of GERD in Pars Cohort Study [PCS] and to find its correlates
Methods: We used the baseline data from PCS. PCS was conducted in the district of Valashahr in Fars province in southern Iran from 2012 to 2014. 9264 inhabitants who were 40-75 years old, and agreed to participate were enrolled. Data were collected by a structured questionnaire and simple physical examination of all participants
Results: Generally, 58.50% [95% CI 57.49 - 59.51] of the participants had GERD and 25.10% [95% CI 24.22 - 25.99] experienced it at least weekly. Approximately, 32.0%, 52.0%, and 24.4% of the participants reported heart burn sensation, regurgitation, and both symptoms, respectively. Being female [OR: 1.45, 95% CI 1.27 - 1.65], being older [OR: 1.20, 95% CI 1.06 - 1.36], being divorced/ widowed/separated [OR: 1.38, 95% CI 1.01 - 1.91], and lower education [OR: 1.43, 95% CI 1.02 - 2.03] were associated with frequent GERD
Conclusion: GERD is common in PCS and its prevalence is close to that in western countries. Being female, higher age, being divorced/widowed/separated, lower education, history of hypertension, anxiety, insomnia, and non-cigarette tobacco smoking were associated with frequent GERD. We are going to investigate the causal relationship between these risk factors and GERD in the next stages of PCS